The Importance of Nutrition in Reversing Neuropathy

Good nutrition is often the first line of defense to avoid many diseases, including peripheral neuropathy. The best way to prevent peripheral neuropathy is to carefully manage any medical condition that puts you at risk. That means controlling your blood sugar level if you have diabetes or talking to your doctor about safe and effective treatments if you think you may have a problem with alcohol. Whether or not you have a medical condition, eat a healthy diet rich in fruits, vegetables, whole grains, and lean protein. Keep a food diary so you are aware of what you’re eating and make sure you get all the nutrients you need each day to stay as healthy as possible.

A Diet to Improve Nerve Health

If you have a nerve disorder like diabetic neuropathy then a diet rich in certain nutrients can help. The food you eat can improve your nervous system’s functioning. Knowing which nutrients nourish your nervous system can help you lead a healthier life and reduce your chances of nerve-related problems.

  • Establish your diet around vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources
  • Aim for 5-10 servings of colorful fruits and/or vegetables daily (phytonutrients). 1 serving = 1/2 cup for all other fruits and vegetables
    • 1 medium fruit or vegetable, for example, apple, orange
    • 1/4 cup dried fruit
    • 3/4 cup juice
  • Limit/avoid alcohol
    • Alcohol has a toxic effect on your nervous system
  • Be aware of sodium; use <2,300 mg per day
  • Lower saturated fats and trans fatty acids by choosing lean meats and poultry, and low-fat or non-fat dairy products
  • Choose monounsaturated fats and polyunsaturated fats (from fish, nuts, and vegetable oils) in lieu of saturated and trans fats
  • Choose/prepare foods and beverages with little added sugars/caloric sweeteners

What helps Reverse Diabetic Neuropathy

The following supplements have been shown to reverse Diabetic Neuropathy and Diabetes.

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Vitamins that Help Your Nerves Heal

VITAMIN E
• Powerful antioxidant that reduces levels of free radicals and oxidative stress
• Protects against side effects: numbness, tingling, burning, and pain
B COMPLEX: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9
(folic acid), B12 (cobalamins)
• B12 deficiency results in damage to the protective covering of nerves
 Decrease in pain (B1/B6/B12)  Folic acid (B9): maintenance of nerve cells
R-ALPHA‐LIPOIC ACID
• Benefit in diabetic neuropathy (less pain, burning, and numbness)
 Further studies are needed for the safety/efficacy of ALA in the prevention/treatment of chemotherapy-induced neuropathy. Get the R-Alpha Lipoic Acid
GLUTAMINE
• A neutral nonessential amino acid thought to have neuroprotective effects (particularly with Paclitaxel)
GLUTATHIONE
• Tripeptide thought to prevent neurotoxicity
 Efficacy was seen in 50 advanced gastric cancer undergoing cisplatin‐based chemotherapy
MAGNESIUM/CALCIUM
• Improvements in neurotoxicity following infusion; helps with cramping
• Caution: may cause diarrhea in large doses
 More research to evaluate its use as a prevention/treatment of chemotherapy-induced neuropathy
N‐ACETYLCYSTEINE (AMINO ACID)
 Powerful antioxidant: Animal studies have shown inhibition of diabetic neuropathy and protection against
neuropathies caused by chemotherapy drugs
OMEGA‐3 FATTY ACIDS
 High quantities of cold-water fish (salmon) and widely consumed for anti‐inflammatory powers
 Essential fatty acids and an important component of cell membranes, the myelin sheath that protects nerves
 Studies show the ability to reduce demyelination of nerves and neuropathic pain
Vitamins B-1, B-6, and B-12
These vitamins have been found to be especially beneficial for treating neuropathy. Vitamin B-1, also known as thiamine, helps to reduce pain and inflammation and vitamin B-6 preserves the covering of nerve endings.B-6 Vitamin.
Tumeric 
Tumeric or Curcumin is a strong antioxidant found in turmeric known for its anti-inflammatory and analgesic properties. When taken early on, curcumin has been found to prevent chronic pain associated with neuropathy. It has also been shown to reduce pain and inflammation. It can be taken as a supplement or used as an herbal add-on to certain foods. 
Fish Oil
Fish oil works as an anti-inflammatory and can repair nerve damage. Research has shown that fish oil can slow the progression of neuropathy and can even reverse it in some cases. It also promotes neuron outgrowth. Fish oil can be taken as a supplement or it can be found in salmon, sardines, mackerel, cod liver oil, herring, oysters, anchovies, or caviar. The omega-3 fatty acids found in fish oil can also be found in walnuts, canola oil, chia seeds, flaxseeds, and soybeans. 
Acetyl-L-carnitine 
Acetyl-L-carnitine is an amino acid and antioxidant. It may raise energy levels, create healthy nerve cells, and reduce pain in people with neuropathy. You can take it as a supplement. A typical dosage is 500 milligrams twice per day.

A List of Drugs that May cause or worsen your Neuropathy

Peripheral neuropathy, which involves damage to the peripheral nerves, can have various causes, including certain drugs and medications. Below are some categories and examples of drugs known to potentially cause or contribute to peripheral neuropathy:

1. Chemotherapy Agents
Platinum-based drugs (e.g., Cisplatin, Carboplatin)
Taxanes (e.g., Paclitaxel, Docetaxel)
Vinca alkaloids (e.g., Vincristine)
Bortezomib (used in multiple myeloma treatment)
2. Antibiotics
Metronidazole
Nitrofurantoin
Linezolid
Isoniazid (used for tuberculosis)
3. Antiviral Drugs
HIV medications like didanosine, stavudine, and zalcitabine (Nucleoside Reverse Transcriptase Inhibitors or NRTIs)
4. Antiseizure Drugs
Phenytoin
Carbamazepine
5. Statins (Cholesterol-lowering Drugs)
Drugs like simvastatin, atorvastatin, or lovastatin have been associated with neuropathy in rare cases.
6. Alcohol and Toxic Substances
Chronic alcohol consumption can also contribute to peripheral neuropathy due to its neurotoxic effects.
Heavy metals (e.g., lead, mercury, arsenic) and certain industrial chemicals.
7. Immunosuppressive Agents
Tacrolimus and cyclosporine can lead to neuropathic symptoms.
8. Diabetes Medications
Thiazolidinediones (like rosiglitazone and pioglitazone) may contribute to peripheral neuropathy.
If drug-induced peripheral neuropathy is suspected, consulting a healthcare provider is essential, as adjustments to medication or treatments may be necessary.

Additional List of Drugs that May cause Neuropathy

Allipurinol
Almitrine Bimismtlate
Amiodarone
Amitryptyline
Ara-C
Bortezomib
Carbamide
Chloramphenicol
Chloroquine
Cipro
Clioquinol
Colchicine
Cyanate
Cyclosporine
Danosine
Dichloacetate
Disopyramide
Disulfiram
Docetaxel
Enalapril
Ethambutol
Ethionamide
Etoposide
Glutethimide
Hydrazaline
Imipramine Trycyclic antidepressants
Isoniazide
Ixabepilone
Leflunomide
Levaquin
Lithium
Mercury
Methaqualone
Metronidazole
Nitrofuantoin
Paclitaxel
Phenelzine